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Search All Research Studies
Topics
- Anxiety (1)
- Behavioral Health (1)
- Caregiving (1)
- Children/Adolescents (2)
- Chronic Conditions (2)
- Depression (2)
- Hospital Readmissions (1)
- Human Immunodeficiency Virus (HIV) (1)
- Medication (1)
- Patient-Centered Outcomes Research (1)
- Quality of Life (1)
- (-) Respiratory Conditions (8)
- Risk (3)
- Sleep Problems (1)
- Social Determinants of Health (1)
- Substance Abuse (1)
- (-) Tobacco Use (8)
- Tobacco Use: Smoking Cessation (1)
AHRQ Research Studies
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Research Studies is a compilation of published research articles funded by AHRQ or authored by AHRQ researchers.
Results
1 to 8 of 8 Research Studies DisplayedOates GR, Baker E, Rowe SM
Tobacco smoke exposure and socioeconomic factors are independent predictors of pulmonary decline in pediatric cystic fibrosis.
This longitudinal study evaluates the effects of tobacco smoke exposure and socioeconomic factors on pulmonary decline in pediatric cystic fibrosis (CF). Data from the CF Foundation Patient Registration was obtained for patients who were 6-18 years old at the end of 2016. Lung function measures (ppFEV(1)) for 10,895 individuals was calculated at each attained age. At age 6, lung function was 4.7% lower among smoke-exposed children than among unexposed with this deficit continuing through age 18. Smoke exposure and socioeconomic factors had independent, additive associations with lung function. Factors that declined ppFEV(1) include smoke exposure (2.4%), lower paternal education (4.9%), public insurance (0.3%), and increased 0.2% with each $10,000 annual household income.
AHRQ-funded; HS023009.
Citation: Oates GR, Baker E, Rowe SM .
Tobacco smoke exposure and socioeconomic factors are independent predictors of pulmonary decline in pediatric cystic fibrosis.
J Cyst Fibros 2020 Sep;19(5):783-90. doi: 10.1016/j.jcf.2020.02.004..
Keywords: Children/Adolescents, Respiratory Conditions, Tobacco Use, Social Determinants of Health, Risk
Oates GR, Harris WT, Gutierrez HH
Tobacco smoke exposure in pediatric cystic fibrosis: a qualitative study of clinician and caregiver perspectives on smoking cessation.
This qualitative study identified barriers and facilitators of smoking cessation in caregivers to children with cystic fibrosis (CF) and outlined potential interventional approaches. Researchers conducted semi-structured interviews with CF familial caregivers who were current or former smokers, and with members of the CF care team, asking about experiences, practices, and prerequisites for a successful program. Findings revealed intrapersonal, interpersonal, and structural barriers to eliminating tobacco smoke exposure in children with CF, outlined opportunities to address these barriers, and made recommendations for a comprehensive tobacco cessation strategy.
AHRQ-funded; HS023009.
Citation: Oates GR, Harris WT, Gutierrez HH .
Tobacco smoke exposure in pediatric cystic fibrosis: a qualitative study of clinician and caregiver perspectives on smoking cessation.
Pediatr Pulmonol 2020 Sep;55(9):2330-40. doi: 10.1002/ppul.24879..
Keywords: Children/Adolescents, Tobacco Use, Tobacco Use: Smoking Cessation, Caregiving, Respiratory Conditions
Parekh TM, Bhatia S, Cherrington A
Factors influencing decline in quality of life in smokers without airflow obstruction: the COPDGene study.
This study looked at factors influencing decline in quality of life (QoL) in smokers without airflow obstruction using participants from the COPDGene study, a multicenter, longitudinal US study designed to determine genetic determinants of chronic obstructive pulmonary disease (COPD). The authors hypothesized that exacerbations and changes in exacerbation status would predict QoL decline among normal spirometry and Preserved Ratio Impaired Spirometry (PRISm) populations. They enrolled study subjects from Phase 1 of COPDGene and performed multivariable logistic regression models to determine independent predictors of decline in quality of life. Independent predictors of QoL deterioration included current smoking, higher exacerbation frequency, and a change from infrequent to frequent exacerbation status in both groups.
AHRQ-funded; HS023009.
Citation: Parekh TM, Bhatia S, Cherrington A .
Factors influencing decline in quality of life in smokers without airflow obstruction: the COPDGene study.
Respir Med 2020 Jan;161:105820. doi: 10.1016/j.rmed.2019.105820..
Keywords: Respiratory Conditions, Chronic Conditions, Tobacco Use, Quality of Life
Iyer AS, Holm KE, Bhatt SP
Symptoms of anxiety and depression and use of anxiolytic-hypnotics and antidepressants in current and former smokers with and without COPD - a cross sectional analysis of the COPDGene cohort.
This study compared the frequency of anxiety/depressive symptoms of current and former smokers with and without COPD and their use of anxiolytic-hypnotics/antidepressants. A cohort of 5331 current/former smokers were surveyed. About 25% of smokers with and without COPD had anxiety/depressive symptoms. Unmedicated smokers tended to be African American, male, have no health insurance, have severe-very severe COPD and higher respiratory symptoms/exacerbation history.
AHRQ-funded; HS023009; HS013852.
Citation: Iyer AS, Holm KE, Bhatt SP .
Symptoms of anxiety and depression and use of anxiolytic-hypnotics and antidepressants in current and former smokers with and without COPD - a cross sectional analysis of the COPDGene cohort.
J Psychosom Res 2019 Mar;118:18-26. doi: 10.1016/j.jpsychores.2019.01.002..
Keywords: Anxiety, Medication, Respiratory Conditions, Depression, Behavioral Health, Anxiety, Tobacco Use
Donovan LM, Rise PJ, Carson SS
Sleep disturbance in smokers with preserved pulmonary function and chronic obstructive pulmonary disease.
This study compared the magnitude and correlates of sleep disturbance between smokers with preserved pulmonary function and those with airflow obstruction. It found that among smokers with clinically identified chronic obstructive pulmonary disease (COPD), the severity of sleep disturbance is greater among those with preserved pulmonary function compared to those with airflow obstruction. Non-respiratory symptoms, such as depression, were associated with sleep disturbance in both groups.
AHRQ-funded; HS017894.
Citation: Donovan LM, Rise PJ, Carson SS .
Sleep disturbance in smokers with preserved pulmonary function and chronic obstructive pulmonary disease.
Ann Am Thorac Soc 2017 Dec;14(12):1836-43. doi: 10.1513/AnnalsATS.201706-453OC.
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Keywords: Respiratory Conditions, Sleep Problems, Tobacco Use, Chronic Conditions
Sood A, Petersen H, Qualls C
Spirometric variability in smokers: transitions in COPD diagnosis in a five-year longitudinal study.
The researchers hypothesized that spirometrically-defined chronic obstructive pulmonary disease (COPD) states could undergo beneficial transitions. Their observational study of ever smokers, shows that spirometrically-defined COPD states, may not be uniformly progressive and can improve or resolve over time. The implication of these findings is that the spirometric diagnosis of COPD can be unstable.
AHRQ-funded; HS023093.
Citation: Sood A, Petersen H, Qualls C .
Spirometric variability in smokers: transitions in COPD diagnosis in a five-year longitudinal study.
Respir Res 2016 Nov 10;17(1):147. doi: 10.1186/s12931-016-0468-7.
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Keywords: Tobacco Use, Respiratory Conditions, Patient-Centered Outcomes Research
Iyer AS, Bhatt SP, Garner JJ
Depression is associated with readmission for acute exacerbation of chronic obstructive pulmonary disease.
The authors characterized the associations between depression and anxiety and COPD readmission risk. They found that depression is an independent risk factor for both short- and long-term readmissions for acute exacerbation of COPD and may represent a modifiable risk factor. They also found that in-hospital tobacco cessation counseling was associated with reduced 1-year readmission.
AHRQ-funded; HS013852.
Citation: Iyer AS, Bhatt SP, Garner JJ .
Depression is associated with readmission for acute exacerbation of chronic obstructive pulmonary disease.
Ann Am Thorac Soc 2016 Feb;13(2):197-203. doi: 10.1513/AnnalsATS.201507-439OC.
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Keywords: Respiratory Conditions, Depression, Hospital Readmissions, Risk, Tobacco Use
Depp TB, McGinnis KA, Kraemer K
Risk factors associated with acute exacerbation of chronic obstructive pulmonary disease in HIV-infected and uninfected patients.
This study sought to determine the association between HIV infection and other risk factors for acute exacerbation of chronic obstructive pulmonary disease (AECOPD). It concluded that HIV infection, especially with lower CD4 cell count, is an independent risk factor for AECOPD. Enhanced susceptibility to harm from current smoking or unhealthy alcohol use in HIV-infected patients may also contribute to the greater rate of AECOPD.
AHRQ-funded; HS023258.
Citation: Depp TB, McGinnis KA, Kraemer K .
Risk factors associated with acute exacerbation of chronic obstructive pulmonary disease in HIV-infected and uninfected patients.
AIDS 2016 Jan 28;30(3):455-63. doi: 10.1097/qad.0000000000000940.
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Keywords: Respiratory Conditions, Human Immunodeficiency Virus (HIV), Risk, Substance Abuse, Tobacco Use