National Healthcare Quality and Disparities Report
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AHRQ Research Studies
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Research Studies is a compilation of published research articles funded by AHRQ or authored by AHRQ researchers.
Results
451 to 463 of 463 Research Studies DisplayedNeugebauer R, Fireman B, Roy JA
Impact of specific glucose-control strategies on microvascular and macrovascular outcomes in 58,000 adults with type 2 diabetes.
This study used comparative effectiveness research methods to compare the effect of four distinct glucose-control strategies on subsequent myocardial infarction and nephropathy in type 2 diabetes. It found that in a large group of adults with type 2 diabetes, more aggressive glucose-control strategies have mixed short-term effects on microvascular complications and do not reduce the myocardial infarction rate over 4 years of follow-up.
AHRQ-funded; 29020050033I.
Citation: Neugebauer R, Fireman B, Roy JA .
Impact of specific glucose-control strategies on microvascular and macrovascular outcomes in 58,000 adults with type 2 diabetes.
Diabetes Care 2013 Nov;36(11):3510-6. doi: 10.2337/dc12-2675..
Keywords: Comparative Effectiveness, Diabetes, Outcomes, Patient-Centered Outcomes Research, Treatments
Zeidan AM, Gore SD, McNally DL
AHRQ Author: Davidoff AJ
Lenalidomide performance in the real world: patterns of use and effectiveness in a Medicare population with myelodysplastic syndromes.
The authors examined the use of lenalidomide in the Medicare population. They found that reductions in transfusion rates were overall consistent with data from clinical trials, and response rates were higher when ≥ 3 lenalidomide cycles were received.
AHRQ-authored.
Citation: Zeidan AM, Gore SD, McNally DL .
Lenalidomide performance in the real world: patterns of use and effectiveness in a Medicare population with myelodysplastic syndromes.
Cancer 2013 Nov 1;119(21):3870-8. doi: 10.1002/cncr.28298.
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Keywords: Comparative Effectiveness, Elderly, Medicare, Medication
Navarro-Millán I, Sattui SE, Curtis JR
Systematic review of tumor necrosis factor inhibitor discontinuation studies in rheumatoid arthritis.
The objective of this article is to conduct a systematic review of the available literature on discontinuation of anti-tumor necrosis factor (anti-TNF) agents in rheumatoid arthritis (RA) patients and the associated features of study designs, including eligibility criteria, outcome definitions, and outcomes of discontinuation. The authors concluded that discontinuation of anti-TNF therapy is achievable for many RA patients who start in clinical remission or low disease activity.
AHRQ-funded; HS018517
Citation: Navarro-Millán I, Sattui SE, Curtis JR .
Systematic review of tumor necrosis factor inhibitor discontinuation studies in rheumatoid arthritis.
Clin Ther. 2013 Nov;35(11):1850-61.e1. doi: 10.1016/j.clinthera.2013.09.015..
Keywords: Comparative Effectiveness, Outcomes, Arthritis, Medication, Chronic Conditions
Raebel MA, Xu S, Goodrich GK
Initial antihyperglycemic drug therapy among 241 327 adults with newly identified diabetes from 2005 through 2010: a surveillance, prevention, and management of diabetes mellitus (SUPREME-DM) study.
This study sought to identify predictors of initiating any antihyperglycemic medication, and specifically sulfonylurea versus metformin in patients with newly diagnosed with diabetes. Most (59.7 percent) patients with newly diagnosed diabetes did not start any antihyperglycemic medication. Among those who did, metformin was generally the first antihyperglycemic initiated.
AHRQ-funded; HS019859
Citation: Raebel MA, Xu S, Goodrich GK .
Initial antihyperglycemic drug therapy among 241 327 adults with newly identified diabetes from 2005 through 2010: a surveillance, prevention, and management of diabetes mellitus (SUPREME-DM) study.
Ann Pharmacother. 2013 Oct;47(10):1280-91. doi: 10.1177/1060028013503624..
Keywords: Diabetes, Medication, Comparative Effectiveness
Nurgalieva ZZ, Franzini L, Morgan RO
Utilization of lymph node dissection, race/ethnicity, and breast cancer outcomes.
This study reports on the impact of nodal surgery utilization on survival among white, African American, Hispanic, and Asian women in a large population of women with breast cancer. It found that the disparities in survival among African American and Hispanic women with breast cancer are not explained by nodal surgery utilization among women with micrometastasis and macrometastasis in sentinel lymph nodes.
AHRQ-funded; HS018956.
Citation: Nurgalieva ZZ, Franzini L, Morgan RO .
Utilization of lymph node dissection, race/ethnicity, and breast cancer outcomes.
Am J Manag Care 2013 Oct;19(10):805-10..
Keywords: Cancer: Breast Cancer, Comparative Effectiveness, Disparities, Patient-Centered Outcomes Research, Racial and Ethnic Minorities
Suskind AM, Clemens JQ, Dunn RL
Effectiveness of mesh compared with nonmesh sling surgery in Medicare beneficiaries.
This study assessed the effectiveness of mesh compared to nonmesh slings in the surgical treatment of female incontinence. It found that overall rates of complications were similar for patients undergoing either mesh or nonmesh sling procedures. However, patients undergoing the nonmesh procedure were more likely to require a subsequent intervention for bladder outlet obstruction.
AHRQ-funded; HS018726.
Citation: Suskind AM, Clemens JQ, Dunn RL .
Effectiveness of mesh compared with nonmesh sling surgery in Medicare beneficiaries.
Obstet Gynecol. 2013 Sep;122(3):546-52. doi: 10.1097/AOG.0b013e31829e8543..
Keywords: Comparative Effectiveness, Elderly, Patient-Centered Outcomes Research, Surgery, Women, Outcomes, Medicare, Evidence-Based Practice
Quick B, Harrison TR, King AJ
It's up to you: a multi-message, phased driver facility campaign to increase organ donation registration rates in Illinois.
This project applied successful strategies previously employed in driver facility campaigns to examine whether these strategies would be effective in growing a registry where the majority of individuals have already had the opportunity to register as an organ donor. In facilities with historically high and low registration percentages, these strategies resulted in higher organ donor registration rates, compared with control facilities.
AHRQ-funded; HS019218
Citation: Quick B, Harrison TR, King AJ .
It's up to you: a multi-message, phased driver facility campaign to increase organ donation registration rates in Illinois.
Clin Transplant. 2013 Sep-Oct;27(5):E546-53. doi: 10.1111/ctr.12208..
Keywords: Comparative Effectiveness, Registries, Transplantation, Education: Patient and Caregiver, Evidence-Based Practice
Dahabreh IJ, Chung M, Kitsios GD
Survey of the methods and reporting practices in published meta-analyses of test performance: 1987 to 2009.
The researchers performed a survey of meta-analyses of test performance to describe the evolution in their methods and reporting. They found that the most common clinical areas were cardiovascular disease and oncology, while the most common test categories were imaging and biomarker tests. They concluded that the methods employed in meta-analyses of test performance have improved with the introduction of quality assessment checklists and the development of more sophisticated statistical methods.
AHRQ-funded; 290200710055I; HS013328.
Citation: Dahabreh IJ, Chung M, Kitsios GD .
Survey of the methods and reporting practices in published meta-analyses of test performance: 1987 to 2009.
Res Synth Methods 2013 Sep;4(3):242-55. doi: 10.1002/jrsm.1083.
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Keywords: Comparative Effectiveness, Diagnostic Safety and Quality, Research Methodologies
Jonsson Funk M, Visco AG, Weidner AC
Long-term outcomes of vaginal mesh versus native tissue repair for anterior vaginal wall prolapse.
This study estimated the rate of repeat surgery after vaginal mesh versus native tissue repair for anterior vaginal wall prolapse. The researchers found that the overall risk of any future surgery was higher in the women receiving mesh; however, native tissue and vaginal mesh surgery had similar 5-year risks for recurrent prolapse.
AHRQ-funded; HS017950
Citation: Jonsson Funk M, Visco AG, Weidner AC .
Long-term outcomes of vaginal mesh versus native tissue repair for anterior vaginal wall prolapse.
Int Urogynecol J. 2013 Aug;24(8):1279-85. doi: 10.1007/s00192-013-2043-9..
Keywords: Comparative Effectiveness, Surgery, Women, Outcomes, Risk
Schneeweiss S, Seeger JD, Jackson JW
AHRQ Author: Smith SR
Methods for comparative effectiveness research/patient-centered outcomes research: from efficacy to effectiveness.
This article provides an overview of papers in this supplement resulting from a June 2012 AHRQ-sponsored symposium on research methods for CER and patient-centered outcomes research.
AHRQ-authored.
Citation: Schneeweiss S, Seeger JD, Jackson JW .
Methods for comparative effectiveness research/patient-centered outcomes research: from efficacy to effectiveness.
J Clin Epidemiol 2013 Aug;66(8 Suppl):S1-4. doi: 10.1016/j.jclinepi.2013.05.012.
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Keywords: Comparative Effectiveness, Evidence-Based Practice, Patient-Centered Healthcare, Patient-Centered Outcomes Research, Research Methodologies
Huang SS, Septimus E, Kleinman K
Targeted versus universal decolonization to prevent ICU infection.
In this pragmatic, cluster-randomized trial the authors compared targeted versus universal decolonization of patients in intensive care units (ICUs) as strategies for preventing health care-associated infections, particularly those caused by methicillin-resistant Staphylococcus aureus (MRSA). They found that in routine ICU practice, universal decolonization was more effective than targeted decolonization or screening and isolation in reducing rates of MRSA clinical isolates and bloodstream infection from any pathogen.
AHRQ-funded; 290201000008I.
Citation: Huang SS, Septimus E, Kleinman K .
Targeted versus universal decolonization to prevent ICU infection.
N Engl J Med 2013 Jun 13;368(24):2255-65. doi: 10.1056/NEJMoa1207290..
Keywords: Comparative Effectiveness, Infectious Diseases, Healthcare-Associated Infections (HAIs), Methicillin-Resistant Staphylococcus aureus (MRSA), Intensive Care Unit (ICU), Patient-Centered Healthcare, Patient Safety, Prevention
Mark TL, Lawrence W, Coffey RM
AHRQ Author: Lawrence W, Steiner C
The value of linking hospital discharge and mortality data for comparative effectiveness research.
The purpose of this paper was to demonstrate the value of linking state community hospital discharge data to vital statistics death files for research by conducting a comparative effectiveness analysis. The analysis revealed that in the matched cohort, in-hospital and 30-day postdischarge mortality rates were significantly lower following endovascular aneurysm repair than open aneurysm repair, but differences in the 1- and 5-year rates were not statistically significant.
AHRQ-authored.
Citation: Mark TL, Lawrence W, Coffey RM .
The value of linking hospital discharge and mortality data for comparative effectiveness research.
J Comp Eff Res 2013 Mar;2(2):175-84. doi: 10.2217/cer.13.4.
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Keywords: Comparative Effectiveness, Data, Healthcare Cost and Utilization Project (HCUP), Mortality, Surgery
Zhang M, Del Fiol G, Grout RW
Automatic identification of comparative effectiveness research from Medline citations to support clinicians' treatment information needs.
The goal of this study was to design and assess an algorithm for automatically identifying comparative effectiveness studies on the treatment of a given condition and extracting the interventions investigated in these studies. A total of 86% of the interventions extracted perfectly or partially matched the gold standard. The researchers concluded that, overall, the algorithm achieved reasonable performance.
AHRQ-funded; HS018352.
Citation: Zhang M, Del Fiol G, Grout RW .
Automatic identification of comparative effectiveness research from Medline citations to support clinicians' treatment information needs.
Stud Health Technol Inform 2013;192:846-50..
Keywords: Comparative Effectiveness, Evidence-Based Practice, Clinical Decision Support (CDS)